A CRITICAL REVIEW ON ETIO-PATHOGENESIS (NAIDANIKA SAMPRAPTI) OF NON-ALCOHOLIC STEATOHEPATITIS (YAKRIT ROGA)

Abstract

Non alcoholic steato hepatitis(NASH) is the more severe form of Non Alcoholic Fatty Liver Disease(NAFLD) becoming not only cause for liver related mortality and morbidity but also responsible for increased susceptibility of atherosclerosis, cardiovascular disease and type 2diabetes mellitus. In India the prevalence of NAFLD is 9 to 32% in general population and it found to be of higher  prevalence in  those with obesity or overweight and those with diabetes and prediabetes. Approximately 25% of NASH patients Over a period of 10 to 15 years may progress to cirrhosis. Currently FDA (Food and Drug Administrative Agency) approved pharmacologic treatment options for NASH are not available. The NASH can be correlated to Yakrit Roga in Ayurveda. No detailed description regarding the disease is available in classics. So here  unique attempt has been made to understand the hetu (cause), samprapthi(pathogenesis) of NASH on the basis of risk factors associated with NAFLD/NASH like obesityperlipidemia,  type 2 diabetes mellitus  and other metabolic syndrome. It can be considered that the nidana of Santarpanajanya Vyadhi, medho roga(atishoulya) and Prameha may be the nidana for NAFLD/NASH and samprapthi is build. Apatarpana chikitsa may be useful.