Scientometric Analysis of Global and Indian Stroke Research with Focus on Contributions of Ayurveda: An Analytical Review
DOI:
https://doi.org/10.70066/jahm.v14i8.2862Keywords:
Analytical review, Ayurveda, Scientometric analysis, StrokeAbstract
Background: Stroke is a leading cause of morbidity and mortality. Due to its rising prevalence, researchers and clinicians across the globe are focusing on its prevention and improving prognosis. This study presents the scientometric analysis of stroke research focusing on contributions of Ayurveda. Objectives: The objective of this study is to analyse research trends in Indian and global stroke literature, to identify major research domains and emerging themes and to evaluate the contribution of Ayurveda in stroke research. Materials and Methods: This is an analytical review done by using descriptive scientometric analysis technique. Science Direct, PubMed database, Google Scholar and AYUSH Research Portal were searched to collect publication data of last 10 years (2016-2025). The search results were analysed for indicators such as publication count, document type, subject areas, journal titles, publication trend and contributions of Ayurveda. Results: Total 32 Ayurveda publications on clinical research on stroke were retrieved. Among all stroke publications, majority were Research articles. In India, most of these publications appeared in “Materials Today: Proceedings” and in Ayurveda, “Journal of Ayurveda and Integrative Medicine” was the most productive journal for stroke research. There was a shift in stroke research trends form emergency management including anticoagulants and thrombectomy to long-term recovery, rehabilitation, and personalized care in the recent years. Ayurveda contributes to integrative stroke management, with evidence supporting role of Panchakarma and herbal formulations in post-stroke rehabilitation and functional recovery. Conclusion: The study depicts rising trends in stroke research globally and in India. Focusing on integrating conservative medicine with complementary medicine is need of an hour.
References
World Health Organization. Stroke [Internet]. 19 December 2025 [cited 2026 May 6]. Available from: https://www.who.int/news-room/fact-sheets/detail/stroke
GBD 2021 Stroke Risk Factor Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Neurology (Lancet Neurol.). 2024 Oct;23(10):973-1003. Available from: https://doi.org/10.1016/S1474-4422(24)00369-7
Satynarayana Shastri, editor. Charaka Samhita of Charaka with Chakrapani’s Dipika Commentary. Sutra Sthana, Chapter 20, verse 10. Reprint ed. Varanasi: Chaukhambha Orientalia Publication, 2nd Edition; 2009; 399.
Leydesdorff L, Milojevid S. Scientometrics. In: Wright JD, editor. International Encyclopedia of the Social & Behavioral Sciences. 2nd ed. Elsevier; 2015. 322-327. https://doi.org/10.1016/B978-0 08-097086-8.85030-8
Belaguli G, Nithin SA. Stage-wise management of Pakshaghata (Ischemic stroke with left hemiplegia) through Ayurveda – A case report. Indian Journal of Ayurveda & Integrative Medicine KLEU (IJAIM KLEU). 2022;3(2),88–93. Available from: https://doi.org/10.4103/ijaim.ijaim_25_21
Mukhedkar AR, Thakar AB, Gandhi RS. An approach of Ayurveda clinical diagnosis in managing acute Pakshavadha (~hemiplegia): A case report. Journal of Ayurveda Case Reports (JACR). 2023;6(3), 98–102. Available from: https://doi.org/10.4103/jacr.jacr_107_22
Nithin SA, Belaguli G, Mohan K. Customized Ayurveda Approaches In Modulating Brain Injury: A Case Report. Journal of Ayurveda Case Reports (JACR). 2022;5(2):68–73. Available from: https://doi.org/10.4103/jacr.jacr_46_22
Patra SR, Panda PK, Dash DP, Acharya R. A Case Study on the Management of Hemiplegia (Intracranial Hemorrhage) Through Various Panchakarma Modalities. Journal of Research in Ayurvedic Sciences (JRAS). 2023;7(4):236–242. Available from: https://doi.org/10.4103/jras.jras_183_22
Mohan V, Divya B, Deva S. Ayurvedic Management of Pakshaghata (Left Hemiplegia) – A Case Study. International Journal of Ayurvedic Medicine (IJAM). 2021;12(3):733–741. Available from: https://doi.org/10.47552/ijam.v12i3.1706
Singh V, Sawarkar P, Sawarkar G, Parwe S. Hemiparesis Management – Cerebral Vascular Event (CVE) Through Panchakarma, Shamana Treatment and Physiotherapy: A Case Report. Journal Of Ayurveda and Integrated Medical Sciences (JAIMS). 2024;9(3):297–302. Available from: https://doi.org/10.21760/jaims.9.3.46
Bhasimon P, Mohan A, Sourabh R. Ayurveda as a Supportive Treatment: A Case Report On Integrative Management of Intracranial Haemorrhage. Journal Of Natural Remedies (JNR). 2024;24(2):373–378. Available from: https://doi.org/10.18311/jnr/2024/35507
Dhiman JK, Prasanth D, Mahapatra AK, Bhatted SK. Management of Cerebrovascular Accident (CVA) Through Ayurveda. Journal of Ayurveda Case Reports (JACR). 2017;1(2):22–29. Available from: https://doi.org/10.4103/2456-5506.220727
Sylaja PN, Nambiar V, Narayan S, Pr J, Kumar CS, Nk P, Menon MM, Berieau VB, Nair D, Dhasan A, Arora D, Verma SJ, Sharma M, Dhaliwal RS, Sarma PS, Pandian JD. Ayurvedic Treatment in the Rehabilitation of Ischemic Stroke Patients In India: A Randomized Controlled Trial (RESTORE). International Journal of Stroke (Int J Stroke). 2025 Dec;20(10):1214–1224. Available from: https://doi.org/10.1177/17474930251349727
Sankaran R, Kamath R, Nambiar V, Kumar A. A Prospective Study on the Effects of Ayurvedic Massage In Post-Stroke Patients. Journal of Ayurveda and Integrative Medicine (JAIM). 2019;10(2):126–130. Available from: https://doi.org/10.1016/j.jaim.2018.02.137
Syed AA, Reza MI, Singh P, Thombre GK, Gayen JR. Withania Somnifera in Neurological Disorders: Ethnopharmacological Evidence, Mechanism of Action and Its Progress in Delivery Systems. Current Drug Metabolism (Curr Drug Metab). 2021;22(7):561–571. Available from: https://doi.org/10.2174/1389200222666210203182716
Rani K, Tyagi M, Mazumder M, Singh A, Shanmugam A, Dalal K, Pillai M, Samudrala G, Kumar S, Srinivasan A. Accelerated Identification of Serine Racemase Inhibitor from Centella Asiatica. Scientific Reports (Sci Rep). 2020 Mar 13;10(1):4640. Available from: https://doi.org/10.1038/s41598-020-61494-1
Harini JA, Luthra A, Madeka S, Shankar P, Mandava P, Pervaje R, Aaron S, Purushotham A. Ayurvedic Treatment of Acute Ischemic Stroke: A Prospective Observational Study. Global Advances in Health and Medicine (Glob Adv Health Med). 2019 May 30;8. Available from: https://doi.org/10.1177/2164956119849396
Mundugaru R, Sivanesan S, Popa-Wagner A, Udaykumar P, Kirubagaran R, Kp G, Vidyadhara DJ. Pluchea Lanceolata Protects Hippocampal Neurons from Endothelin-1 Induced Ischemic Injury to Ameliorate Cognitive Deficits. Journal Of Chemical Neuroanatomy (J Chem Neuroanat). 2018 Dec;94:75–85. Available from: https://doi.org/10.1016/j.jchemneu.2018.09.002
Jhelum P, Wahul AB, Kamle A, Kumawat S, Kumar A, Bhutani KK, Tripathi SM, Chakravarty S. Sameerpannag Ras Mixture (SRM) Improved Neurobehavioral Deficits Following Acute Ischemic Stroke by Attenuating Neuroinflammatory Response. Journal Of Ethnopharmacology (J Ethnopharmacol). 2017 Feb 2;197:147–156. Available from: https://doi.org/10.1016/j.jep.2016.07.059
Jaideep SS, Nagaraja D, Pal PK, Sudhakara D, Talakad SN. Modulation Of Cardiac Autonomic Dysfunction in Ischemic Stroke Following Ayurveda (Indian System of Medicine) Treatment. Evidence-Based Complementary and Alternative Medicine (Evid Based Complement Alternat Med). 2014;2014:634695. Available from: https://doi.org/10.1155/2014/634695
Donnan GA, Davis SM, Parsons MW, Ma H, Dewey HM, Howells DW. How To Make Better Use of Thrombolytic Therapy in Acute Ischemic Stroke. Nature Reviews Neurology (Nat Rev Neurol). 2011;7(7):400–409. Available from: https://doi.org/10.1038/nrneurol.2011.89
Sanelli PC, Sykes JB, Ford AL, Lee JM, Vo KD, Hallam DK. Imaging and Treatment of Patients with Acute Stroke: An Evidence-Based Review. American Journal of Neuroradiology (AJNR). 2014;35(6):1045–1051. Available from: https://doi.org/10.3174/ajnr.A3518
Fugate JE, Rabinstein AA. Update On Intravenous Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke. Mayo Clinic Proceedings (Mayo Clin Proc). 2014;89(7):960–972. Available from: https://doi.org/10.1016/j.mayocp.2014.03.001
Berkhemer OA, Fransen PSS, Beumer D, van den Berg LA, Lingsma HF, Yoo AJ, Schonewille WJ, Vos JA, Nederkoorn PJ, Wermer MJH, van Walderveen MAA, Staals J, Hofmeijer J, van Oostayen JA, Lycklama à Nijeholt GJ, Boiten J, Brouwer PA, Emmer BJ, de Bruijn SFTM, van Dijk LC, Kappelle LJ, Lo RH, van Dijk EJ, de Vries J, de Kort PLM, van Rooij WJ, van den Berg JS, van Hasselt BA, Aerden LAM, Dallinga RJ, Visser MC, Bot JCA, Vroomen PC, Eshghi O, Schreuder THCM, Heijboer RJJ, Keizer K, Tielbeek AV, den Hertog HM, Gerrits DG, van den Berg-Vos RM, Karas GB, Steyerberg EW, Flach HZ, Marquering HA, Sprengers ME, Jenniskens SFM, Beenen LFM, van den Berg R, Oppenheim C, Majoie CBLM, van Zwam WH, Wijnhoud AD, van der Lugt A, Roos YB, Fonseca AC, Dippel DWJ. A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke. The New England Journal of Medicine (N Engl J Med). 2015;372(1):11–20. Available from: https://doi.org/10.1056/NEJMoa1411587
Campbell BCV, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, Yan B, Dowling RJ, Parsons MW, Oxley TJ, Wu TY, Brooks M, Simpson MA, Miteff F, Levi CR, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Priglinger M, Ang T, Scroop R, Barber PA, McGuinness B, Wijeratne T, Phan TG, Chong W, Chandra RV, Bladin CF, Badve M, Rice H, de Villiers L, Ma H, Desmond PM, Parsons LS, Butcher KS, Peeling J, Genovese J, Flanagan P, Churilov L, Donnan GA. Endovascular Therapy For Ischemic Stroke With Perfusion-Imaging Selection. The New England Journal of Medicine (N Engl J Med). 2015;372(11):1009–1018. Available from: https://doi.org/10.1056/NEJMoa1414792
Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, Roy D, Jovin TG, Willinsky RA, Sapkota BL, Dowlatshahi D, Frei DF, Kamal NR, Montanera WJ, Poppe AY, Ryckborst KJ, Silver FL, Shuaib A, Tampieri D, Heran MK, Fox AJ, Hill MD. Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke. The New England Journal of Medicine (N Engl J Med). 2015;372(11):1019–1030. Available from: https://doi.org/10.1056/NEJMoa1414905
Saver JL, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, Albers GW, Cognard C, Cohen DJ, Hacke W, Jansen O, Jovin TG, Mattle HP, Nogueira RG, Siddiqui AH, Yavagal DR, Baxter BW. Stent-Retriever Thrombectomy After Intravenous t-PA Vs. t-PA Alone in Stroke. The New England Journal of Medicine (N Engl J Med). 2015;372(24):2285–2295. Available from: https://doi.org/10.1056/NEJMoa1415061
Albers GW, Marks MP, Kemp S, Christensen S, Tsai JP, Ortega-Gutierrez S, McTaggart RA, Torbey MT, Kim-Tenser M, Leslie-Mazwi T, Sarraj A, Kasner SE, Ansari SA, Yeatts SD, Hamilton S, Mlynash M, Heit JJ, Zaharchuk G, Kim S, Carrozzella J, Palesch YY, Martin CO, Lavori PW, Lansberg MG, Bammer R, DEFUSE 3 Investigators. Thrombectomy For Stroke At 6 To 16 Hours with Selection by Perfusion Imaging. The New England Journal of Medicine (N Engl J Med). 2018;378(8):708–718. Available from: https://doi.org/10.1056/NEJMoa1713973
Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, Yavagal DR, Ribo M, Cognard C, Hanel RA, Sila CA, Hassan AE, Millan M, Levy EI, Mitchell P, Chen M, English JD, Shah QA, Silver FL, Pereira VM, Mehta BP, Baxter BW, Abraham MG, Cardona P, Veznedaroglu E, Hellinger FR, Feng L, Kirmani JF, Lopes DK, Jankowitz BT, Frankel MR, Costalat V, Vora NA, Yoo AJ, Malik AM, Furlan AJ, Rubiera M, Aghaebrahim A, Olivot JM, Tekle WG, Shields R, Graves T, Lewis RJ, Smith WS, Liebeskind DS, Saver JL, Jovin TG, DAWN Trial Investigators. Thrombectomy 6 To 24 Hours After Stroke with a Mismatch Between Deficit and Infarct. The New England Journal of Medicine (N Engl J Med). 2018;378(1):11–21. Available from: https://doi.org/10.1056/NEJMoa1706442
Campbell BCV, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM, Donnan GA. Ischaemic Stroke. Nature Reviews Disease Primers (Nat Rev Dis Primers). 2019;5(1):70. Available from: https://doi.org/10.1038/s41572-019-0118-8
Cramer SC, Dodakian L, Le V, See J, Augsburger R, McKenzie A, Zhou RJ, Chiu NL, Heckhausen J, Cassidy JM. Efficacy of Home-Based Telerehabilitation Vs In-Clinic Therapy for Adults After Stroke. JAMA Neurology (JAMA Neurol). 2021;78(9):1079–1087. Available from: https://doi.org/10.1001/jamaneurol.2021.2338
Ward NS, Brander F, Kelly K. Intensive Upper Limb Neurorehabilitation in Chronic Stroke: Outcomes, Evidence, And Future Directions. The Lancet Neurology (Lancet Neurol). 2019;18(8):800–812. Available from: https://doi.org/10.1016/S1474-4422(19)30135-9
Venketasubramanian N. A Prospective Study on the Effects of Ayurvedic Massage In Post-Stroke Patients. Journal Of Ayurveda and Integrative Medicine (JAIM). 2019;10(2):126–130. Available from: https://doi.org/10.1016/j.jaim.2018.02.137
Sowmiya S, Begum RF, Dhivya LS, Rajendran P, Harikrishnan N, Singh AS. Traditional, Complementary, And Integrative Medicine in the Management of Ischemic Stroke: A Narrative Review. Frontiers in Pharmacology (Front Pharmacol). 2025;16:1561688. Available from: https://doi.org/10.3389/fphar.2025.1561688
Singh N, Bhalla M, de Jager P, Gilca M. Ashwagandha in Brain Disorders: A Review of Recent Developments. Journal of Ethnopharmacology (J Ethnopharmacol). 2020;257:112876. Available from: https://doi.org/10.1016/j.jep.2020.112876
Dubey T, Chinnathambi S. Brahmi (Bacopa Monnieri): An Ayurvedic Herb Against Alzheimer's Disease. Archives of Biochemistry and Biophysics (Arch Biochem Biophys). 2019;676:108153. Available from: https://doi.org/10.1016/j.abb.2019.108153
Shalini VT, Neelakanta SJ, Sriranjini JS. Neuroprotection with Bacopa Monnieri: A Review of Experimental Evidence. Molecular Biology Reports (Mol Biol Rep). 2021;48(3):2653–2668. Available from: https://doi.org/10.1007/s11033-021-06236-w
Poondla N, Babaeizad A, Sheykhhasan M. Exosome-Based Therapies and Biomarkers in Stroke: Current Advances and Future Directions. Experimental Neurology (Exp Neurol). 2025;391:115286. Available from: https://doi.org/10.1016/j.expneurol.2025.115286
Zhang Y, Xue J, Zhang K, Sun M. Basic Research Progress of Exosomes in the Diagnosis and Treatment of Stroke. Chinese Journal of Brain Diseases and Rehabilitation (Chin J Brain Dis Rehabil). 2025;15(5):309–313. Available from: https://doi.org/10.3877/cma.j.issn.2095-123X.2025.05.010
Marín-Medina DS, Arenas-Vargas PA, Arias-Botero JC, Gómez-Vásquez M, Jaramillo-López MF. Artificial Intelligence in Stroke Rehabilitation: From Acute Care to Long-Term Recovery. Neuroscience (Neuroscience). 2025;572:214–231. Available from: https://doi.org/10.1016/j.neuroscience.2025.03.017
Huang L, Shi X, Zhang N, Gao Y, Bai Q, Liu L, Zuo L. Bibliometric Analysis of Trends and Issues in Traditional Medicine for Stroke Research: 2004–2018. BMC Complementary Medicine and Therapies (BMC Complement Med Ther). 2020;20:39. Available from: https://doi.org/10.1186/s12906-020-2832-x
Feigin VL, Stark BA, Johnson CO. Global, Regional, And National Burden of Stroke and Its Risk Factors, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019. The Lancet Neurology (Lancet Neurol). 2021;20(10):795–820. Available from: https://doi.org/10.1016/S1474-4422(21)00252-0
Kim J, Thayabaranathan T, Donnan GA, Howard G, Howard VJ, Rothwell PM, Feigin VL, Norrving B, Owolabi M, Pandian J, Liu L, Cadilhac DA, Thrift AG. Global Stroke Statistics 2019. International Journal of Stroke (Int J Stroke). 2020;15(8):819–838. Available from: https://doi.org/10.1177/1747493020909545
Guo W, Wang Y, Fan M, Xie S, Zhao H, Wang J, Liu Y, Xu D, Xu Y. Integrating Metabolomics and Network Pharmacology to Explore the Protective Effect of Gross Saponins Of Tribulus Terrestris L. Fruit Against Ischemic Stroke in Rat. Journal Of Ethnopharmacology (J Ethnopharmacol). 2020;263:113202. Available from: https://doi.org/10.1016/j.jep.2020.113202
Younis NS, Mohamed ME. Sandalwood Oil Neuroprotective Effects on Middle Cerebral Artery Occlusion Model of Ischemic Brain Stroke. Pharmacognosy Magazine (Pharmacogn Mag). 2020;16(68):117–122. Available from: https://doi.org/10.4103/pm.pm_398_19
Masatkar PR. Clinical Effect of Shirodhara in Pakshaghat with Special Reference to Cerebral Ischemic Stroke. International Journal of Research in Ayurveda and Pharmacy (IJRAP). 2018;9(4):17–20. Available from: https://doi.org/10.7897/2277-4343.094101
Rais A, Tanwar SR, Prasher B, Thakar AB. Management of Stroke Through Virechana: A Case Report. Journal of Ayurveda Case Reports (JACR). 2019;2(2):9–17. Available from: https://doi.org/10.4103/jacr.jacr_6_19
Patil P, Diggavi M, Patil AS. Role of Agnilepa in Pakshaghata (Ischemic Stroke): A Case Study. International Journal of Research in Ayurveda and Pharmacy (IJRAP). 2021;12(4):4–8. Available from: https://doi.org/10.7897/2277-4343.120495
Belaguli G, Nithin SA. Stage-Wise Management of Pakshaghata (Ischemic Stroke with Left Hemiplegia) Through Ayurveda: A Case Report. Indian Journal of Ayurveda and Integrative Medicine (IJAIM). 2022;3(2):88–93. Available from: https://doi.org/10.4103/ijaim.ijaim_25_21
Sori A, Pervaje R, Prasad BS. An Individualized Treatment Protocol Development in the Management of Pakshaghata (Acute Stage of Ischemic Stroke): A Review. International Journal of Research in Ayurveda and Pharmacy (IJRAP). 2017;8(5):10–13. Available from: https://doi.org/10.7897/2277-4343.085253
Bushra O, Mangalasseri P. Focus Group Discussion on Development of Structured Satvavajaya Module for Stroke Patient. International Journal of Research in Ayurveda and Pharmacy (IJRAP). 2018;9(3):47–52. Available from: https://doi.org/10.7897/2277-4343.09373
Singh R, Ota S, Khanduri S, Rani S, Bhadula A, Sharma R, Shahi VK, Bharti, Srikanth N, Dhiman KS. Integration of AYUSH (Ayurveda and Yoga) with National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS): An Appraisal of Central Council for Research in Ayurvedic Sciences Research and Development Initiatives. Journal of Research in Ayurvedic Sciences (JRAS). 2018;2(1):27–36. Available from: https://doi.org/10.4103/jras.jras_6_18
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