Integrative Management of Diabetic Foot Gangrene: A Case Report
DOI:
https://doi.org/10.70066/jahm.v14i3.2565Keywords:
Ayurveda, case report, diabetic foot, flap necrosis, gangrene, integrative medicine, KothaAbstract
Background: Diabetic foot gangrene (DFG) remains a major clinical challenge, particularly in patients with coexisting peripheral arterial disease. This coexistence can delay intervention, which may lead to limb loss. In Ayurveda, this condition can be considered under the concept of Kotha and Dushtavrana. Ayurveda texts clearly state the multimodal management strategy for the same. Clinical Findings: A 41-year-old male with a history of Type 2 diabetes mellitus for 1 year presented with black discoloration of the first to third toes of the left foot associated with swelling, pus discharge, and sensory loss. Imaging and clinical features supported the diagnosis of both Buerger’s disease and Diabetic foot gangrene. After careful assessment, the overall presentation favored the diagnosis of DFG. Based on Ayurveda principles, the diagnosis of Vata-pittaja dushta vrana was made. Intervention: Chedana karma in the form of disarticulation of the second and third toes and debridement of the first toe was done, followed by conservative treatment. A single dose of prophylactic antibiotic was given before the procedure. It included Panchatiktak ghrita guggulu, Gandharva haritaki churna orally, Jatyadi ghrita application locally, and Jalauka-avacharana (leech therapy) for a total of seven alternate-day sittings. Management also included continuation of antidiabetic medication, smoking cessation, and routine supportive measures in the form of offloading using Microcellular rubber footwear and a diabetic diet. Outcome: Complete (100%) wound healing was seen within 14 days without any flap necrosis. Vibration perception threshold reduced from 30V (severe neuropathy) to 22 V (normal). The patient was able to resume his regular duties within a month. No adverse event was observed during the treatment. The patient was followed up for 1 year, and no recurrence of symptoms was observed. Conclusion: This case demonstrates integrative approach to the management of diabetic foot gangrene is beneficial in preventing major limb loss and disability.
References
Bhargava A, Mahakalkar C, Kshirsagar S. Understanding Gangrene in the Context of Peripheral Vascular Disease: Prevalence, Etiology, and Considerations for Amputation-Level Determination. Cureus. 2023 Nov 18;15(11):e49026. https://doi.org/10.7759/cureus.49026
Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376(24):2367–2375. https://doi.org/10.1056/NEJMra1615439
Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y. Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis. Ann Med. 2017;49(2):106–116.https://doi.org/10.1080/07853890.2016.1231932
Ólafsdóttir AF, Svensson AM, Pivodic A, Gudbjörnsdottir S, Nyström T, Wedel H, Rosengren A, Lind M. Excess risk of lower extremity amputations in people with type 1 diabetes compared with the general population: amputations and type 1 diabetes. BMJ Open Diabetes Res Care. 2019;7(1):e000602. https://doi.org/10.1136/bmjdrc-2018-000602
Liu H, Liu J, Wu Y, Ma Y, Zhou M, Xue Y, Rui Y. Analysis of the risk factors for free flap necrosis in soft tissue reconstruction of the lower limbs. Orthop Surg. 2023;15(6):1534–1540. https://doi.org/10.1111/os.13727
Sahu S, Rao SP, Satapathy T, Sen K, Pradhan B. Recent advancement and future strategies for the care and management of diabetic foot ulcer complications: A systemic approach to Pharmacotherapy for successful wound repair and healing. Journal of Drug Delivery & Therapeutics. 2025 Jun 1;15(6). https://doi.org/10.22270/jddt.v15i6.7242
Tan CH, Wu Y, Satkunanantham M. Flaps for lower limb diabetic wound reconstruction: A systematic review and meta-analysis. Journal of plastic, reconstructive & aesthetic surgery. 2023 Apr 1; 79:74-86. https://doi.org/10.1016/j.bjps.2023.01.032
Raja JM, Maturana MA, Kayali S, Khouzam A, Efeovbokhan N. Diabetic foot ulcer: A comprehensive review of pathophysiology and management modalities. World journal of clinical cases. 2023 Mar 16;11(8):1684. https://doi.org/10.12998/wjcc.v11.i8.1684
Aerden D, Massaad D, von Kemp K, van Tussenbroek F, Debing E, Keymeulen B, Van den Brande P. The ankle–brachial index and the diabetic foot: a troublesome marriage. Annals of vascular surgery. 2011 Aug 1;25(6):770-7. https://doi.org/10.1016/j.avsg.2010.12.025
Mousavian A, Sabzevari S, Parsazad S, Moosavian H. Leech Therapy Protects Free Flaps against Venous Congestion, Thrombus Formation, and Ischemia/Reperfusion Injury: Benefits, Complications, and Contradictions. Arch Bone Jt Surg. 2022;10(3):252-260. https://doi.org/10.22038/abjs.2022.55013.2736
Sreechand SSR, Hemalata K, Shindhe PS, Arya M, Anil A. Ayurvedic approach to the management of Dry Gangrene (Vrana Kotha) In Peripheral Vascular Disease: A case report. JAHM. 2025 Jun 19;13(5):168-75. https://doi.org/10.46607/jahm.v13i5.1805
Sreenadh P, Dudhamal T. Multidisciplinary approach of Ayurveda and conventional principles in the management of diabetic foot ulcer - DFU: A Case Report. JAHM. 2025 Oct;13(10):139-149. https://doi.org/10.70066/jahm.v13i10.2405
Yadavaji Trikamaji (editor). Sushruta Samhita of Sushruta, Chikitsasthana, chapter 1, verse no.33. 2nd edition, Varanasi: Chowkhambha Surabharati Prakashana;2018;400.
Karigar SB. Classical utility of Panchatikta Guggulu Ghrita in its indications-literary review. Int Ayurvedic Med J. 2021;9(6):1266–1273. https://doi.org/10.46607/iamj1909062021
Téot, L. Leeches in Prevention of Skin Necrosis in Flap Surgery. In: Téot, L., Meaume, S., Akita, S., Del Marmol, V., Probst, S. (eds) Skin Necrosis. Springer, Cham; 2024 https://doi.org/10.1007/978-3-031-60954-1_50
Mahesh, K. ROLE OF AYURVEDIC MEDICINES AND LEECH THERAPY IN MANAGEMENT OF BUERGER’S DISEASES – A CASE REPORT. Journal of Ayurveda and Holistic Medicine (JAHM)2021 Mar, 2(8). https://doi.org/10.70066/jahm.v2i8.204
Yadavaji Trikamaji (editor). Sushruta Samhita of Sushruta, Sharirasthana, chapter 7, verse no.14. 2nd edition, Varanasi: Chowkhambha Surabharati Prakashana;2018;377.
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